Harriet Beecher was a member of one of the 19th century’s most remarkable families. The daughter of the prominent Congregationalist minister Lyman Beecher and the sister of Catharine, Henry Ward, and Edward, she grew up in an atmosphere of learning and moral earnestness. She attended her sister Catharine’s school in Hartford, Connecticut, in 1824–27, thereafter teaching at the school. In 1832 she accompanied Catharine and their father to Cincinnati, Ohio, where he became president of Lane Theological Seminary and she taught at another school founded by her sister.

In Cincinnati she took an active part in the literary and school life, contributing stories and sketches to local journals and compiling a school geography, until the school closed in 1836. That same year she married Calvin Ellis Stowe, a clergyman and seminary professor, who encouraged her literary activity and was himself an eminent biblical scholar. She wrote continually and in 1843 published The Mayflower; or, Sketches of Scenes and Characters Among the Descendants of the Pilgrims.